New Metronidazole Oral SUSPENSION

The ONLY US FDA-approved ready-to-use oral liquid metronidazole

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LIKMEZ®

(metronidazole) Oral Suspension
500 mg/5 mL

A safe and efficacious option for patients who struggle with traditional oral tablet formulations.

LIKMEZ® is the first US FDA-approved liquid formulation of metronidazole for the treatment of antimicrobial infections. It addresses the need:

  • For patients who have trouble swallowing pills, helping them to stay on their medication
  • For patients who have trouble with the taste of regular metronidazole, helping them to stay on their medication
  • To help reduce the potential risks that can occur when medication is compounded

Patients who stay on their medication have a better chance of successfully fighting their infection and keeping it from being harder to treat future infections.

LIKMEZ® is the only US FDA-approved liquid form of metronidazole, now providing an option for patients who have trouble swallowing or taste-related compliance issues.

Important Safety Information

What is LIKMEZ?
LIKMEZ is an antibiotic medicine used to treat:

  • trichomoniasis (a sexually transmitted infection) in adults
  • amebiasis (an infection caused by a parasite) in adults and children
  • anaerobic bacterial infections (infections caused by bacteria that do not need oxygen to survive) in adults

It is not known if LIKMEZ is safe and effective in children, except for the treatment of amebiasis.

Do not take LIKMEZ if you:

  • are allergic to metronidazole or other nitroimidazole medicines.
  • have taken disulfiram (medicine used to help people stop drinking alcohol) in the last 2 weeks. Taking LIKMEZ with disulfiram can cause psychotic symptoms (seeing or hearing things that are not really there) in people who drink alcohol.
  • drink alcohol or use products with propylene glycol during treatment with LIKMEZ and for at least 3 days after you stop taking LIKMEZ, because this can cause side effects including abdominal cramps, nausea, vomiting, headaches, and flushing.
  • have Cockayne Syndrome (a rare genetic disorder that affects growth and development).

Before taking LIKMEZ, tell your healthcare provider about all of your medical conditions, including if you:

  • have liver problems.
  • have kidney problems.
  • have medical problems that affect the brain.
  • have a yeast infection.
  • have a history of blood problems.
  • are breastfeeding or plan to breastfeed. LIKMEZ can pass into your breastmilk. Talk to your healthcare provider about the best way to feed your baby while taking LIKMEZ. If you are breastfeeding, you may consider pumping and throwing away your breast milk during treatment with LIKMEZ and for 48 hours after your last dose of LIKMEZ and feeding your infant stored human milk or formula.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins and herbal supplements. LIKMEZ and other medicines can affect each other causing side effects.

Especially tell your healthcare provider if you take:

  • warfarin or other blood thinners (anticoagulants)
  • lithium
  • busulfan
  • cimetidine
  • phenytoin and phenobarbital

You can ask your pharmacist for a list of medicines that interact with LIKMEZ.

Know the medicines you take. Keep a list of them to show your healthcare provider and pharmacist when you get a new medicine.

What are the possible side effects of LIKMEZ?

LIKMEZ may cause serious side effects including:

  • Nervous system problems, including brain disorder (encephalopathy), inflammation of the brain and spinal cord membranes (aseptic meningitis), numbness or tingling in the hands or feet (peripheral neuropathy) and seizures (convulsions). Tell your healthcare provider right away if you have any nervous system problems while taking LIKMEZ.
  • Worsening yeast infection (candidiasis) symptoms in people with a known yeast infection or a yeast infection they were not aware of.
  • Low white blood cell count (leukopenia) in people with a history of blood problems. This can affect how well the body fights infection.

The most common side effects of LIKMEZ include:  nausea, headache, anorexia, vomiting, diarrhea, pain in the upper abdomen, abdominal cramping, and constipation.

Other side effects of LIKMEZ include:

  • allergic reactions: such as itching, hives (urticaria), flushing of the skin, red skin rash that can be widespread, blisters and separation of skin layers, nasal congestion, dryness of the mouth and vagina, and fever
  • abnormal heart rhythm (QT prolongation)

These are not all the possible side effects of LIKMEZ. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1‑800‑FDA-1088.

General information about the safe and effective use of LIKMEZ.

Medicines are sometimes prescribed for purposes other than those listed in the product labeling. Do not use LIKMEZ for a condition for which it was not prescribed. Do not give LIKMEZ to other people, even if they have the same symptoms that you have. It may harm them.

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